Ciprofloxacin-loaded alginate/poly (vinyl alcohol)/gelatin electrospun nanofiber mats as antibacterial wound dressings

Herein, ciprofloxacin (CIP)-loaded alginate/poly (vinyl alcohol)/gelatin (SPG) (CIP–SPG) nanofiber mats were successfully fabricated by electrospinning. The average fiber diameters of the before and after crosslinking in range 190–260 385–484 nm, respectively. chemical integrity CIP remained intact encapsulation into mats. degree weight loss water swelling decreased with an increase gelatin content electrospun A release study was carried out total immersion diffusion methods using phosphate buffer as a medium. Burst observed case method, while more sustained method. maximum amounts released during 70–90% 72–85%, For both methods, slowed down content; this result is consistent values. Young’s modulus increased, tensile strength strain at break content. CIP–SPG slightly toxic to L929 mouse fibroblasts evaluated indirect cytotoxicity assay. exhibited excellent antimicrobial activity against Staphylococcus aureus Escherichia coli. These results reveal that are potentially promising materials for wound healing applications.